Pd-Catalyzed Triple-Fold C(sp2)-H Activation with Enaminones and Alkenes for Pyrrole Synthesis via Hydrogen Evolution

The synthesis of NH-free pyrroles via Pd-catalyzed annulation of enaminones and alkenes is reported. With the catalysis of Pd(II), the activation of triple C(sp(2))-H bonds, including one internal C(sp(2))-H bond in enaminone, has been activated to provide various pyrroles. The interesting evolution of hydrogen gas from the reactions has been observed by a hydrogen detector.

Automated summary

The study reported the synthesis of NH-free pyrroles via Pd-catalyzed annulation of enaminones and alkenes, activating multiple C-H bonds and producing a variety of products, with the interesting observation of hydrogen gas evolution during the reactions.