A Readily Available Trifluoromethylation Reagent and Its Difunctionalization of Alkenes

Trifluoromethyl substitution is notably popular in pharmaceuticals and agrochemicals; however, trifluoromethylated compounds normally rely on the use of cost-prohibitive or gaseous trifluoromethylating reagents, which diminishes the general applicability of these methods. Herein an efficient trifluoromethylation reagent trifluoromethyl-sulfonyl-pyridinium salt (TFSP) was reported, which can be readily prepared from cheap and easily available bulk industrial feedstocks. TFSP can generate a trifluoromethyl radical under photocatalysis and realize the effective azidoor cyano-trifluoromethylation reactions of alkenes.

Automated summary

TFSP, an efficient trifluoromethylation reagent, can be readily prepared from cheap industrial feedstocks, enabling effective trifluoromethylation reactions of alkenes under photocatalysis.