Photocatalytic C-H Trifluoromethylthiolation by the Decatungstate Anion

A broadly applicable method for the trifluorome-thylthiolation of methylene C(sp(3))-H, methine C(sp(3))-H, alpha-oxygen C(sp(3))-H, and formyl C(sp(2))-H bonds is presented using the decatungstate anion as the sole catalyst. By adjusting the substrate ratio and reaction concentration, this method was applied to 40 examples in good regioselectivities, including the derivatization of natural products. Furthermore, SCF3-drug analogues were synthesized by subsequent functionalization of the SCF3 products, highlighting the importance of this photocatalyzed C-H functionalization.

Automated summary

A broadly applicable method for trifluorome-thylthiolation of various types of C-H bonds using decatungstate anion as the sole catalyst has been developed, achieving good regioselectivities in 40 examples, including natural product derivatization. Additionally, SCF3-drug analogues were synthesized by subsequent functionalization of the SCF3 products, highlighting the importance of this photocatalyzed C-H functionalization.