期刊
ORGANIC LETTERS
卷 23, 期 13, 页码 5164-5169出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01702
关键词
-
资金
- ERDF [121]
- EPSRC [EP/K039466/1]
- NZP
- EPSRC [EP/K039466/1] Funding Source: UKRI
The article presents a practical procedure for preparing a range of 2-substituted 1,4-cubanedicarboxylic ester derivatives through a radical-mediated chlorocarbonylation process, along with a subsequent regioselective ester hydrolysis to obtain fully differentiated 1,2,4-trisubstituted cubanes.
The cubane ring has received intense attention as a 3D benzene isostere and scaffold. Mono- and 1,4-disubstituted cubanes are well-described. Here we report a practical procedure for a direct radical-mediated chlorocarbonylation process initially reported by Bashir-Hashemi, to access a range of 2-substituted 1,4-cubanedicarboxylic ester derivatives. A subsequent regioselective ester hydrolysis to give fully differentiated 1,2,4-trisubstituted cubanes is demonstrated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据