期刊
ORGANIC LETTERS
卷 23, 期 14, 页码 5334-5338出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01624
关键词
-
资金
- Robert A. Welch Foundation [C-1680]
- National Science Foundation [CHE-1904865]
The study describes a pair of boronic acid functional groups, NAB and EAB, that enable sequential cross-coupling through stepwise nickel- and copper-catalyzed processes, allowing for the preparation of various bioconjugates.
Boronic acids can play diverse roles when applied in biological environments, and employing boronic acid structures in tandem could provide new tools for multifunctional probes. This Letter describes a pair of boronic acid functional groups, 2-nitro-arylboronic acid (NAB) and (E)-alkenylboronic acid (EAB), that enable sequential cross-coupling through stepwise nickel- and copper-catalyzed processes. The selective coupling of NAB groups enables the preparation of stapled peptides, protein-protein conjugates, and other bioconjugates.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据