期刊
ORGANIC LETTERS
卷 23, 期 15, 页码 5621-5625出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01601
关键词
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资金
- National Natural Science Foundation of China [81991521, 82022069, 42076099]
- National Key Research and Development Program of China [2018YFC0310903]
- Shanghai RisingStar Program [20QA1411100]
- Youth Innovation Promotion Association of CAS [Y202065]
- SKLDR/SIMM Project [SIMM2103ZZ-06]
A novel norditerpenoid and four polyoxygenated cembranoids were isolated from the Hainan soft coral Sinularia siaesensis, with their structures elucidated through various methodologies. The study also proposed a biosynthetic pathway for the novel compound and demonstrated their inhibitory activity against inflammation in BV-2 microglial cells.
A novel norditerpenoid, sinusiaetone A (1), featuring an uncommon bicyclo[11.3.0]hexadecane carbon skeleton, and four polyoxygenated cembranoids (2-5) were isolated from the Hainan soft coral Sinularia siaesensis. Their structures were established by spectroscopic analysis, X-ray diffraction, quantum chemical computational approaches, and/or a modified Mosher's method. A plausible biosynthetic pathway of 1 and its biogenetic relationship with 2-5 were proposed. New compounds 1-3 displayed an interesting inhibitory activity against lipopolysaccharide-induced inflammation in BV-2 microglial cells.
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