期刊
ORGANIC LETTERS
卷 23, 期 18, 页码 7014-7017出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02201
关键词
-
资金
- NSF [CHE-1665145]
- Temple University
The DMM reaction is a method for synthesizing chiral 2-amino cyclohexenes that proceeds at low temperature while maintaining stereochemical fidelity. The product yields range from 55-82%, with diastereomeric ratios as high as >19:1.
The domino Michael/Mannich (DMM) annulation reaction between an N-sulfinyl lithiodienamine and an electrophilic alkene is developed for the synthesis of chiral 2-amino cyclohexenes, a key building block in asymmetric synthesis. The DMM reaction proceeds at low temperature while maintaining the stereochemical fidelity. The product functionalized amino cyclohexenes, here obtained in 55-82% yield with diastereomeric ratios as high as >19:1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据