期刊
ORGANIC LETTERS
卷 23, 期 19, 页码 7359-7363出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02513
关键词
-
资金
- National Natural Science Foundation of China [22071028, 21772024, 21921003]
A practical synthesis of enantioenriched indane derivatives with quaternary stereocenters was developed via sequential enantioselective reduction and C-H functionalization. Good to excellent enantioselectivity could be achieved by either the CuH-catalyzed asymmetric reduction or the Corey-Bakshi-Shibata (CBS) reduction of indanone derivatives. The strategy was further applied in syntheses of (nor)illudalane and botryane sesquiterpenoids.
A practical synthesis of enantioenriched indane derivatives with quaternary stereocenters was developed via sequential enantioselective reduction and C-H functionalization. Good to excellent enantioselectivity could be achieved by either the CuH-catalyzed asymmetric reduction or the Corey-Bakshi-Shibata (CBS) reduction of indanone derivatives. The subsequent diastereo-specific and regioselective rhodium-catalyzed silylation of the methyl C-H bond led to indane derivatives with quaternary centers. This strategy was further applied in syntheses of (nor)illudalane and botryane sesquiterpenoids.
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