Enantioselective Construction of Polycyclic Indazole Skeletons Bearing Five Consecutive Chiral Centers through an Asymmetric Triple-Reaction Sequence

A novel approach for the asymmetric construction of polycyclic indazole skeletons via enamine-imine activation and PCET activation was developed by merging organocatalysis with photocatalysis through an asymmetric triple-reaction sequence. In this process, five C-X bonds and five consecutive chiral centers were efficiently constructed. Differently substituted polycyclic indazole deriatives were successfully constructed with satisfactory results under mild conditions.

Automated summary

A novel approach for the asymmetric construction of polycyclic indazole skeletons was developed by merging organocatalysis with photocatalysis, efficiently constructing five C-X bonds and five consecutive chiral centers. Differently substituted polycyclic indazole derivatives were successfully constructed with satisfactory results under mild conditions.