期刊
ORGANIC LETTERS
卷 23, 期 19, 页码 7325-7329出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02361
关键词
-
资金
- National Natural Science Foundation of China [21825108, 21521002]
This study successfully utilized a chiral frustrated Lewis pair to achieve asymmetric halocyclization of 2-vinylbenzyl alcohols, resulting in optically active 1,3-dihydroisobenofuran derivatives with high yields. These derivatives can be conveniently converted into other useful chiral compounds.
By the use of a chiral frustrated Lewis pair (FLP) consisting of a chiral-diene-derived borane and (Bu3P)-Bu-t as the catalyst, an asymmetric halocyclization of 2-vinylbenzyl alcohols with NBS or NIS was successfully realized. A variety of optically active 1,3-dihydroisobenofuran derivatives were obtained in high yields with up to 87% ee and could be conveniently converted to other useful chiral compounds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据