Oxime Ether Synthesis through O-H Functionalization of Oximes with Diazo Esters under Blue LED Irradiation

A green and sustainable oxime ether formation method via the visible-light-promoted O-H functionalization of oximes with diazo esters is described. The reaction occurs under very mild conditions (catalyst- and additive-free) with a high yield and a high functional group tolerance. When the reaction was performed with a cyclic ether as the solvent (e.g., THF, 1,4-dioxane, tetrahydropyran, ect.), an interesting photochemical three-component reaction product was obtained in good yields.

Automated summary

A green and sustainable oxime ether formation method using visible light to promote the O-H functionalization of oximes with diazo esters is efficient and versatile, with high yields and tolerance to various functional groups. When a cyclic ether solvent is used, such as THF, 1,4-dioxane, and tetrahydropyran, an interesting photochemical three-component reaction product can be obtained in good yields.