期刊
ORGANIC LETTERS
卷 23, 期 18, 页码 7285-7289出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02767
关键词
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资金
- University of Delaware
- NIH [S10OD016267, S10RR026962, S10OD025185, P20GM104316, P30GM110758]
- NIH IDeA Program [NIH P20GM104316]
- Unidel Foundation
- NSF [CHE-0421224, CHE-0840401]
The synthesis of the natural product impatien A was achieved using an aza-Heck cyclization to construct the complex spirocyclic ring system, showcasing an efficient synthetic method. Through high-throughput experimentation, a new ligand was identified to enable the key cyclization reaction, ultimately allowing impatien A to be synthesized in seven steps from known compounds.
The first total synthesis of the natural product impatien A is described. This concise synthesis features an aza-Heck cyclization to construct the complex spirocyclic ring system and provides a rare example of the use of aza-Heck cyclizations in complex molecule synthesis. To enable this key cyclization of an electrophilic nitrogen atom with a tetrasubstituted alkene, we utilized high-throughput experimentation to identify a new ligand and ultimately deliver impatien A in seven steps from known compounds.
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