期刊
ORGANIC LETTERS
卷 23, 期 12, 页码 4538-4542出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01180
关键词
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资金
- NIH NIGMS
- Welch Foundation
- Novartis
- University of Texas at Austin
- Eli Lilly and Co.
A general system for achieving three-component intermolecular carbofunctionalization of alkenes has been presented, including carboetherification, carboesterification, carboarylation, and carboamination. The scope of the reaction involves the carbon electrophile, the olefin, and the nucleophile. Additionally, the synthesis of gamma-lactams through a carboamination reaction was demonstrated in a telescoped three-step protocol.
A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented, including carboetherification, carboesterification, carboarylation, and carboamination. The scope of the reaction is presented with respect to the carbon electrophile, the olefin, and the nucleophile. Furthermore, the synthesis of gamma-lactams via a carboamination reaction is demonstrated in a telescoped three-step protocol.
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