期刊
ORGANIC LETTERS
卷 23, 期 15, 页码 6046-6051出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02114
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This study presents a reductive radical conjugate addition that activates alkyl bromides via cobalt/iridium catalysis to form alkyl radicals, with a broad substrate scope including benzylic halides and halides containing free alcohols, silanes, and chlorides.
Alkyl and aryl halides have been studied extensively as radical precursors; however, mild and less toxic conditions for the activation of alkyl bromides toward alkyl radicals are still desirable. Reported here is a reductive radical conjugate addition that allows for the formation of alkyl radicals via activation of alkyl bromides through cobalt/iridium catalysis. The developed conditions are emphasized in the broad substrate scope presented, including benzylic halides and halides containing free alcohols, silanes, and chlorides.
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