期刊
ORAL ONCOLOGY
卷 118, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.oraloncology.2021.105335
关键词
Machine learning; Tumor burden; Prognosis; Therapeutics; Nasopharyngeal carcinoma
资金
- National Natural Science Foundation of China [81872375, 81572665, 81702873]
- International Science and Technology Cooperation Programme [2016A050502011, 2014A050503033]
- Young Teacher Foundation of Sun Yat-sen University [18ykpy35]
- Science and Technology Planning Project of Guangdong Province [2017B020228003]
The study aimed to build a survival system using a highly-accurate machine learning model and explainable artificial intelligence techniques to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma patients. The proposed system consistently demonstrated promising performance across different cohorts, suggesting that high-risk patients may benefit from induction chemotherapy.
Objectives: We aimed to build a survival system by combining a highly-accurate machine learning (ML) model with explainable artificial intelligence (AI) techniques to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma (NPC) patients using magnetic resonance imaging (MRI)-based tumor burden features. Materials and methods: 1643 patients from three hospitals were enrolled according to set criteria. We employed ML to develop a survival model based on tumor burden signatures and all clinical factors. Shapley Additive exPlanations (SHAP) was utilized to explain prediction results and interpret the complex non-linear relationship among features and distant metastasis. We also constructed other models based on routinely used cancer stages, EpsteinBarr virus (EBV) DNA, or other clinical features for comparison. Concordance index (C-index), receiver operating curve (ROC) analysis and decision curve analysis (DCA) were executed to assess the effectiveness of the models. Results: Our proposed system consistently demonstrated promising performance across independent cohorts. The concordance indexes were 0.773, 0.766 and 0.760 in the training, internal validation and external validation sets. SHAP provided personalized protective and risk factors for each NPC patient and uncovered some novel non-linear relationships between features and distant metastasis. Furthermore, high-risk patients who received induction chemotherapy (ICT) and concurrent chemoradiotherapy (CCRT) had better 5-year distant metastasis-free survival (DMFS) than those who only received CCRT, whereas ICT + CCRT and CCRT had similar DMFS in low-risk patients. Conclusions: The interpretable machine learning system demonstrated superior performance in predicting metastasis in locoregionally advanced NPC. High-risk patients might benefit from ICT.
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