期刊
ORAL DISEASES
卷 27, 期 8, 页码 1947-1976出版社
WILEY
DOI: 10.1111/odi.13993
关键词
dysplasia; grading systems; HPV; oral cancer; oral potentially malignant disorders; pre-cancer; malignant transformation
Histopathological grading of epithelial dysplasia is crucial for assessing the risk of malignant transformation in oral potentially malignant disorders (OPMDs). Current views on molecular pathogenesis, histological interpretation, and the use of grading systems are discussed. The implications of finding epithelial dysplasia in an oral biopsy for clinical management are also highlighted from the pathologists' viewpoint.
Histopathological grading of epithelial dysplasia remains the principal laboratory method for assessing the risk of malignant transformation in oral potentially malignant disorders (OPMDs). Current views on the molecular pathogenesis and histological interpretation of the features of epithelial dysplasia are described, and the use of grading systems for epithelial dysplasia is discussed. Changes to the current 2017 WHO criteria for diagnosis are proposed with emphasis on the architectural features of epithelial dysplasia. The predictive values of three-grade and binary systems are summarised, and categories of epithelial dysplasia are reviewed, including lichenoid and verrucous lesions, keratosis of unknown significance, HPV-associated dysplasia, differentiated and basaloid epithelial dysplasia. The implications of finding epithelial dysplasia in an oral biopsy for clinical management are discussed from the pathologists' viewpoint.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据