期刊
FUTURE MICROBIOLOGY
卷 11, 期 7, 页码 887-902出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2015-0002
关键词
antibiotics; bacterial consortium transplantation; inflammatory bowel disease; intestinal microbiota
类别
资金
- National Program on Key Basic Research Project (973 Program) [2013CB531405]
- National High-Technology Research and Development Program of China (863 Program) [2014AA022200]
- National Natural Science Foundation of China (NSFC) [81370113]
- Research Fund for the Doctoral Program of Higher Education, China (RFDP) [20132105120012]
- Nature Science Foundation of Liaoning Province, China [2015020262]
Aim: To investigate the effects of a defined bacterial consortium on trinitrobenzenesulfonic acid (TNBS)-induced colitis and intestinal dysbiosis in rats. Materials & methods: Rats with TNBS-induced colitis were treated with ceftriaxone and/or a mixture of ten bacterial strains isolated from mouse feces for continuous 24 days. Macroscopic and histopathological parameters in colonic tissue were compared, as were myeloperoxidase enzyme activity and cytokine levels. Patterns of intestinal microbiota were assessed by PCR-denaturing gradient gel electrophoresis, the abundance of selected microbial groups was evaluated by qPCR. Results & conclusion: Transplantation of the bacterial consortium showed anti-inflammatory activity in the intestines of rats with TNBS-induced colitis and contributed to the rapid re-establishment of intestinal microbial equilibrium. A defined bacterial consortium may be a viable therapeutic option for the treatment inflammatory bowel disease.
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