期刊
FUTURE MICROBIOLOGY
卷 11, 期 10, 页码 1279-1297出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2016-0067
关键词
amphotericin B; Candida albicans; catalase; fluconazole; oxidative stress
类别
资金
- Fundacion Carolina
- Instituto de Salud Carlos III
- [PCIN-2014-052]
- [BIO2012-31839]
- [BIO2015-64777-P]
- [SAF2011-25140]
Aim: To investigate the role of Cat1 overproduction in Candida albicans. Materials & methods: Strains overproducing the CAT1 gene were constructed. Results: Cells overproducing CAT1 were found to be more resistant to some oxidants and mammalian phagocytic cells. They also showed reduced intracellular reactive oxygen species generated by amphotericin B or ciclopirox olamine. CAT1 overproduction did not change the minimum inhibitory concentration of fungal cells to fungistatic or fungicidal azoles nor to amphotericin B although increased twofold the minimum inhibitory concentration to caspofungin. The role of Cat1 overproduction in virulence and colonization was also analyzed in mouse models. Conclusion: The overproduction of Cat1 protects against oxidants, phagocytes and certain antifungals at subinhibitory concentration but does not increase virulence in a systemic infection mouse model.
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