期刊
FUTURE MEDICINAL CHEMISTRY
卷 8, 期 12, 页码 1399-1412出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2016-0079
关键词
chemical space; chemoinformatics; fungal metabolites; master key compound; molecular complexity; molecular fingerprint
资金
- Universidad Nacional Autonoma de Mexico (UNAM) [PE200116]
- institutional program Nuevas Alternativas de Tratamiento para Enfermedades Infecciosas (NUATEI) of the Instituto de Investigaciones Biomedicas (IIB) UNAM
- CONACyT [660465/576637]
- National Cancer Institute/NIH, Bethesda, MD, USA [P01 CA125066]
Aim: Fungi are valuable resources for bioactive secondary metabolites. However, the chemical space of fungal secondary metabolites has been studied only on a limited basis. Herein, we report a comprehensive chemoinformatic analysis of a unique set of 207 fungal metabolites isolated and characterized in a USA National Cancer Institute funded drug discovery project. Results: Comparison of the molecular complexity of the 207 fungal metabolites with approved anticancer and nonanticancer drugs, compounds in clinical studies, general screening compounds and molecules Generally Recognized as Safe revealed that fungal metabolites have high degree of complexity. Molecular fingerprints showed that fungal metabolites are as structurally diverse as other natural products and have, in general, drug-like physicochemical properties. Conclusion: Fungal products represent promising candidates to expand the medicinally relevant chemical space. This work is a significant expansion of an analysis reported years ago for a smaller set of compounds (less than half of the ones included in the present work) from filamentous fungi using different structural properties.
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