期刊
FUTURE MEDICINAL CHEMISTRY
卷 8, 期 7, 页码 817-832出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2016-0024
关键词
Ca2+ release-activated Ca2+ channel; CRAC channel inhibitor; ORAI1; STIM1; store-operated Ca2+ entry
资金
- Major Project of Science and Technology of Shandong Province [2015ZDJS04001]
- Fundamental Research Funds of Shandong University [2014JC008]
- NIH [R01GM112003]
Aberrant Ca2+ release-activated Ca2+ (CRAC) channel activity has been implicated in a number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular diseases and cancer, thus placing CRAC channels among the important targets for the treatment of these disorders. We briefly summarize herein the molecular basis and activation mechanism of CRAC channel and focus on discussing several pharmacological inhibitors of CRAC channels with respect to their biological activity, mechanisms of action and selectivity over other types of Ca2+ channel in different types of cells.
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