期刊
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
卷 37, 期 6, 页码 E209-E213出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IOP.0000000000002021
关键词
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资金
- Research to Prevent Blindness
Ocular cicatricial pemphigoid (OCP) may have a subtype with a prolonged early stage of chronic conjunctivitis without fibrosis. Early diagnosis and treatment may be beneficial in preventing complications of the disease.
Ocular cicatricial pemphigoid (OCP) represents an insidious, autoimmune-mediated disease of the conjunctiva, initially presenting as chronic conjunctivitis and progressing to fibrosis, cicatrization, and eventually blindness secondary to corneal keratinization. This series reports 3 cases presenting with chronic conjunctivitis lasting an average of 10 years without cicatrix formation, ultimately diagnosed as OCP based on direct immunofluorescence of conjunctival biopsy samples. This chronic conjunctivitis without fibrosis suggests the possibility of an OCP subtype with a prolonged early stage or prodrome prior to cicatrization, which may benefit from early diagnosis and treatment to prevent complications of this disease.
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