4.8 Review

Going beyond Polycomb: EZH2 functions in prostate cancer

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Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer

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Summary: This study reveals that FOXA1 is a nonhistone substrate of enhancer of zeste homolog 2 (EZH2) which methylates FOXA1 at lysine-295. The methylation is recognized by WD40 repeat protein BUB3 and recruited ubiquitin-specific protease 7 (USP7) to enhance FOXA1 protein stability. EZH2 inhibitors may be leveraged to enhance therapeutic targeting of FOXA1-driven PCa growth.

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