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Efficacy of Tacrolimus in Uveitis, and the Usefulness of Serum Tacrolimus Levels in Predicting Disease Control. Results from a Single Large Center

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OCULAR IMMUNOLOGY AND INFLAMMATION
卷 30, 期 7-8, 页码 1654-1658

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TAYLOR & FRANCIS INC
DOI: 10.1080/09273948.2021.1930063

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Uveitis; Tacrolimus; Immunosuppressant

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Tacrolimus was found to be effective and well tolerated in treating noninfectious uveitis in this study. Higher trough serum tacrolimus concentrations were associated with better disease control, while high-dose use of oral prednisolone was significantly reduced.
Aims: To evaluate the efficacy of tacrolimus in patients with noninfectious uveitis, as well as the usefulness of serum tacrolimus concentration measurements in predicting disease control. Methods: A retrospective review was carried out on 71 eligible patients from a single specialist uveitis center for minimum 1-year follow-up. Analysis was carried out on disease activity, visual acuity, and trough serum tacrolimus concentrations (STC). Results: At 1-year follow-up, disease control was achieved in 49 patients (69.0%), this was significantly more likely in patients with trough STC levels above 5 ng/mL (88% vs 53%, p = .002). There was a significant reduction in oral prednisolone (dose >= 7.5 mg, 86% vs 54%, p < .0001). Tacrolimus was discontinued in 12 patients (17%) due to side effects. Discussion: In this study cohort, oral tacrolimus was effective and well tolerated in the treatment of noninfectious uveitis. Trough STC between 5 ng/mL and 10 ng/ml was associated with better disease control at 1-year follow-up.

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