期刊
NUTRITION REVIEWS
卷 80, 期 5, 页码 1001-1012出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/nutrit/nuab063
关键词
adverse environment; apolipoprotein E; enteric infections; innate immunity; malnutrition; systemic inflammation
资金
- Brazilian National Council for Scientific and Technological Development
- Coordination for the Improvement of Higher Education Personnel Procad [071/2013, 144494]
- Bill and Melinda Gates Foundation [OPP1137923]
- Bill and Melinda Gates Foundation [OPP1137923] Funding Source: Bill and Melinda Gates Foundation
The review highlights the crucial role of the APOE gene in cholesterol metabolism and its immunomodulatory functions. It particularly focuses on the impact of APOE4 on Alzheimer's disease and severity of COVID-19 infection, as well as the importance of APOE gene polymorphism in children's health and development in underprivileged environments.
Apolipoprotein E plays a crucial role in cholesterol metabolism. The immunomodulatory functions of the human polymorphic APOE gene have gained particular interest because APOE4, a well-recognized risk factor for late-onset Alzheimer's disease, has also been recently linked to increased risk of COVID-19 infection severity in a large UK biobank study. Although much is known about apoE functions in the nervous system, much less is known about APOE polymorphism effects on malnutrition and enteric infections and the consequences for later development in underprivileged environments. In this review, recent findings are summarized of apoE's effects on intestinal function in health and disease and the role of APOE4 in protecting against infection and malnutrition in children living in unfavorable settings, where poor sanitation and hygiene prevail, is highlighted. The potential impact of APOE4 on later development also is discussed and gaps in knowledge are identified that need to be addressed to protect children's development under adverse environments.
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