4.4 Review

Obesity and dietary fat influence dopamine neurotransmission: exploring the convergence of metabolic state, physiological stress, and inflammation on dopaminergic control of food intake

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Summary: High-fat diets, particularly those high in saturated fat, are associated with obesity and changes in dopamine neurotransmission. However, little is known about the effect of diets high in unsaturated fat on the dopamine system. This study found that a diet high in saturated fat led to weight gain, impaired blood glucose regulation, and abnormal dopamine release and uptake. In contrast, a diet high in unsaturated fat showed similar metabolic and behavioral parameters as a control diet and preserved normal dopamine signaling.

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