Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke

Background and aims: Gender-specific differences were found in serum uric acid (SUA) levels and the risk of isolated distal deep vein thrombosis (IDDVT). This study aimed to explore the association among gender, SUA, and IDDVT in stroke patients. Methods and results: Finally, 3404 patients were recruited and divided into two groups: IDDVT (n = 1233) and Non-IDDVT (n = 2171) groups. Propensity score matching (PSM) was conducted to match the patients. Binary logistic regression was adopted to explore the association between SUA and IDDVT, with the SUA divided into quartiles. After PSM, 975 patients were included in each group. Non-IDDVT group had a larger proportion of male than IDDVT group (64.9% vs. 52.7%, p < 0.001). Moreover, males showed higher SUA levels than females (316.7 +/- 102.1 vs. 261.8 +/- 94.0 mmol/L, t = 12.1, p < 0.001). The highest quartile of SUA (>346 mmol/L) showed a lower risk of IDDVT (OR = 0.629, p = 0.001), while the lowest quartile (<225 mmol/L) showed a higher risk of IDDVT (OR = 1.361, p = 0.022). Conclusion: In patients with stroke, SUA played a protective role in IDDVT. Females had a higher risk of IDDVT, which may be owing to the lower SUA levels than males. In clinical practice, more attention should be paid to the risk of IDDVT in females, especially those with lower SUA levels. (c) 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Automated summary

The study explored the association among gender, serum uric acid (SUA), and isolated distal deep vein thrombosis (IDDVT) in stroke patients. Male patients had higher SUA levels and lower risk of IDDVT, while female patients had lower SUA levels and higher risk of IDDVT.