期刊
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
卷 74, 期 4, 页码 1322-1337出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/01635581.2021.1952444
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Consumption of GL-rich foods like Brassica vegetables and maca is linked to reduced cancer risk. Maca has significantly higher GL content and shows growth-inhibitory effects against cancer cell lines, supporting its categorization as a superfood.
The consumption of glucosinolate (GL)-rich foods, including Brassica vegetables, such as mustard, broccoli, and maca, is associated with decreased risk of developing cancer. The GL content in maca, which is recognized as a superfood, is approximately 100-times higher than that in other brassicas. Although maca is a potential dietary source of GLs, limited studies have examined the bioactivity of maca GLs using the combination of chemical characterization and bioassays. In this study, the fractions (Lm-II and Lm-III) rich in intact GLs (glucotropaeolin and glucolimnanthin) were isolated and characterized from maca ethanolic extracts using chromatography and mass spectrometry. Additionally, the growth-inhibitory effects of Lm-II and Lm-II fractions against hepatocellular carcinoma (HepG2/C3A) and colon adenocarcinoma (HT29) cell lines were examined in the absence or presence of myrosinase (MYR). Fractions lacking low molecular weight sugars dose-dependently exerted cytotoxic effects in the presence of MYR. The half-maximal inhibitory concentration values of Lm-II and Lm-III against HepG2/C3A were 118.8 and 69.9 mu g/mL, respectively, while those against HT29 were 102.6 and 71.5 mu g/mL, respectively. These results suggest that the anticancer properties of maca can be attributed to GLs and corroborate the categorization of maca as a superfood. Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1952444
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