期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 40, 期 8, 页码 790-797出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2021.1950759
关键词
Hsa-miR-15b-5p; miRNA; RdRp; RNA template component; SARS-CoV-2
资金
- Special Research COVID-19 challenge Fund for Tokyo University of Science
This study found that a specific human microRNA may suppress viral infection and proliferation by targeting the RNA template component of SARS-CoV-2 RdRp.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic of the coronavirus disease in 2019. RNA-dependent RNA polymerase (RdRp) plays an essential role in RNA replication and transcription in SARS-CoV-2. In this study, we focused on the RNA template component of viral RdRp structure and analyzed human microRNAs (miRNAs) targeting specific sequences in this RNA. By examining miRNA databases and using an in vitro RNA-RNA interaction assay, we observed hsa-miR-15b-5p interacting with the RNA component of viral RdRp. Our findings provide evidence that hsa-miR15b-5p may suppresses viral infection and proliferation by targeting the RNA template component of SARS-CoV-2 RdRp.
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