Synthesis, characterization, and DNA binding study of ruthenium(II/III) complexes containing ONS donor Schiff base

A chelating ligand of thioether with ONS donor Schiff base HL [(E)-2-(((2-(benzylthio)phenyl)imino)methyl)napthalen-1-ol] and its metal complexes (RuL1 and RuL2) have been synthesized. They have been characterized by UV-Vis, FTIR, H-1 NMR, C-13 NMR, mass spectrometry methods. The formulas of the synthesized compounds have been confirmed by elemental analysis and magnetic susceptibility measurements. The binding ability studies of the ligand (HL) and its Ru complexes (RuL1 and RuL2), with calf-thymus DNA have been explored by the absorption titration method. The binding interaction study reveals that the ligand (HL) and the complex RuL1 interact with CT-DNA through an intercalative mode of binding whereas the complex RuL2 does not show any interaction with CT-DNA due to steric effect.

Automated summary

A chelating ligand with thioether and ONS donor, Schiff base HL, was synthesized alongside its corresponding metal complexes RuL1 and RuL2. The binding ability studies showed that the ligand HL and complex RuL1 interact with calf-thymus DNA through an intercalative binding mode, while the complex RuL2 did not show any interaction with DNA due to steric effects.