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The Importance of Context in Covid-19 Vaccine Safety

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NEW ENGLAND JOURNAL OF MEDICINE
卷 385, 期 12, 页码 1138-1140

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MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMe2112543

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Vaccine safety is crucial for any vaccination program, as demonstrated by the 1976 Fort Dix incident where a small excess risk of Guillain-Barre syndrome was noted after vaccination. It is important to closely monitor and address any potential risks associated with vaccination programs.
Vaccine safety is critical for the successful implementation of any vaccination program, especially during a pandemic. In February 1976, the Centers for Disease Control and Prevention confirmed a cluster of cases of severe influenza-like illness among Army recruits at Fort Dix, New Jersey.(1) A swine influenza A strain that resembled the 1918 pandemic influenza strain was identified,(2) and a vaccination program was subsequently initiated for the entire U.S. population. After more than 40 million persons were vaccinated, a small excess risk of Guillain-Barre syndrome was noted, with an attributable risk of approximately 1 case per 100,000 doses administered. Given these . . .

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