期刊
NEUROSURGERY
卷 89, 期 3, 页码 413-419出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1093/neuros/nyab176
关键词
Aged; Clinical Study; Gait disorders; Neurologic; Gravitation; Hydrocephalus; Normal pressure; Neurosurgery; Ventriculoperitoneal shunt
Comparing gravitational and flow-regulated shunt valves in NPH patients, it was found that patients with flow-regulated valves required fewer valve adjustments and reoperations during treatment, with comparable clinical outcomes and risk of overdrainage complications compared to gravitational valves.
BACKGROUND: Normal pressure hydrocephalus (NPH) is frequently treatedwith ventriculoperitoneal shunt ( VPS) surgery. However, VPS implantation can lead to overdrainage and complications such as headaches, hygroma, and subdural hematoma due to a siphon effect in an upright position. Gravitational valves prevent overdrainage through positiondependent adjustment of valve resistance. Flow-regulated valves that increase resistance in presence of high cerebrospinal fluid flow may provide similar protection against overdrainage and present an alternative to gravitational valves. OBJECTIVE: To compare gravitational and flow-regulated shunt valves in patients with symptomatic NPH. METHODS: We performed a retrospective analysis of 97 patients suffering from NPH who underwent VPS implantation with a gravitational or a flow-regulated valve. The primary endpoint was the occurrence of hygroma or subdural hematoma. Secondary endpoints were neurological outcome (Kiefer score, Stein and Langfitt score, and NPH recovery rate), frequency of valve adjustments, and reoperations. RESULTS: Nosignificant differences in the occurrence of hygromaand subdural hematoma (11.4% for flow-regulated valves vs 5.7% for gravitational valves, P =.462) or response to treatment (77.3% vs 81.1%, P =.802) were found. Patients with flow-regulated valves required fewer valve adjustments (1.12 vs 2.02, P <.001) to reach their optimal neurological outcome and underwent fewer surgical revisions (11.4% vs 28.3%, P =.047). CONCLUSION: Our data suggest that shunt therapy in NPH patients with a flow-regulated instead of a gravitational valve is safe and effective with a comparable clinical outcome and risk of overdrainage complications. Moreover, patients with flow-regulated valvesmay need fewer valve adjustments and reoperations.
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