期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 127, 期 -, 页码 779-794出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2021.05.022
关键词
PTSD; Substance use disorders; PTSD plus SUD; PTSD comorbidity; Executive functioning; Negative emotionality; Reward salience; Social cognition
资金
- Canadian Institutes of Health Research [201711MFE-395820-229817]
- National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism [AA025853]
The study presents a unifying translational framework to synthesize human laboratory research in four neurofunctional domains related to the co-occurrence of PTSD and SUD. It emphasizes the importance of human experimental studies in each domain and discusses the implications for treatment development.
We provide a unifying translational framework that can be used to synthesize extant lines of human laboratory research in four neurofunctional domains that underlie the co-occurrence of posttraumatic stress and substance use disorders (PTSD+SUD). We draw upon the Alcohol and Addiction Research Domain Criteria (AARDOC) to include executive functioning, negative emotionality, reward, and added social cognition from the National Institute of Mental Health (NIMH) Research Domain Criteria into our framework. We review research findings across each of the four domains, emphasizing human experimental studies in PTSD, SUD, and PTSD+SUD for each domain. We also discuss the implications of research findings for treatment development by considering new ways of conceptualizing risk factors and outcomes at the level of the individual patient, which will enhance treatment matching and advance innovations in intervention.
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