期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 127, 期 -, 页码 865-875出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2021.06.010
关键词
Memory; Epigenetics; Transcriptomics; Engram cells; Next -generation sequencing; Labeling of active neurons; Multiomic analysis; Chromatin modifications
资金
- Spanish Ministry of Education
- Generalitat Valenciana
- MICINN [SAF2017-87928-R, SEV-2013-0317]
- ERDF
- Generalitat Valenciana [PROMETEO/2020/007]
- Human Frontiers Science Program Organization (HFSPO) [RGP0039/2017]
Transcription and epigenetic changes play vital roles in neuronal response to stimulation, impacting enduring changes in animal behavior such as learning and memory. Yet, understanding the specific epigenetic changes occurring in these cells and their contribution to memory persistence remains a challenge despite recent research progress.
Transcription and epigenetic changes are integral components of the neuronal response to stimulation and have been postulated to be drivers or substrates for enduring changes in animal behavior, including learning and memory. Memories are thought to be deposited in neuronal assemblies called engrams, i.e., groups of cells that undergo persistent physical or chemical changes during learning and are selectively reactivated to retrieve the memory. Despite the research progress made in recent years, the identity of specific epigenetic changes, if any, that occur in these cells and subsequently contribute to the persistence of memory traces remains unknown. The analysis of these changes is challenging due to the difficulty of exploring molecular alterations that only occur in a relatively small percentage of cells embedded in a complex tissue. In this review, we discuss the recent advances in this field and the promise of next-generation sequencing (NGS) and epigenome editing methods for overcoming these challenges and address long-standing questions concerning the role of epigenetic mechanisms in memory encoding, maintenance and expression.
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