4.7 Review

Unravelling the impacts of western-style diets on brain, gut microbiota and cognition

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Summary: The consumption of 'western'-style diets and sedentary lifestyles have led to a global epidemic of obesity, with maternal obesity, overnutrition, and unhealthy dietary patterns having lasting adverse effects on offspring's physical and mental health. Studies suggest that maternal overnutrition may disrupt offspring cognitive function, affective state, and psychosocial behavior through mechanisms such as neuroinflammation, disrupted neuronal circuities, dysregulated brain hormones, and changes in gut microbiota. Further research is needed to explore the specific pathways shaping abnormal behavior in offspring in the context of maternal obesogenic diet exposure.

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