期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 127, 期 -, 页码 334-352出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2021.04.036
关键词
Fear conditioning; Memory consolidation; Reconsolidation; Noninvasive brain stimulation; Optogenetic manipulations
资金
- Ministero della Salute, Italy [GR-2018-12365733]
The acquisition and extinction of fear associative memory rely on coordinated neural activity within specific brain regions, particularly the amygdala and prefrontal cortex. By comparing brain networks involved in fear processing in humans and other species, we can gain insights into fear mechanisms and potential treatments for fear-related disorders.
The acquisition of fear associative memory requires brain processes of coordinated neural activity within the amygdala, prefrontal cortex (PFC), hippocampus, thalamus and brainstem. After fear consolidation, a suppression of fear memory in the absence of danger is crucial to permit adaptive coping behavior. Acquisition and maintenance of fear extinction critically depend on amygdala-PFC projections. The robust correspondence between the brain networks encompassed cortical and subcortical hubs involved into fear processing in humans and in other species underscores the potential utility of comparing the modulation of brain circuitry in humans and animals, as a crucial step to inform the comprehension of fear mechanisms and the development of treatments for fear-related disorders. The present review is aimed at providing a comprehensive description of the literature on recent clinical and experimental researches regarding the noninvasive brain stimulation and optogenetics. These innovative manipulations applied over specific hubs of fear matrix during fear acquisition, consolidation, reconsolidation and extinction allow an accurate characterization of specific brain circuits and their peculiar interaction within the specific fear processing.
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