How does caffeine influence memory? Drug, experimental, and demographic factors

Caffeine is a widely used nootropic drug, but its effects on memory in healthy participants have not been sufficiently evaluated. Here we review evidence of the effects of caffeine on different types of memory, and the associated drug, experimental, and demographical factors. There is limited evidence that caffeine affects performance in memory tasks beyond improved reaction times. For drug factors, a dose-response relationship may exist but findings are inconsistent. Moreover, there is evidence that the source of caffeine can modulate its effects on memory. For experimental factors, past studies often lacked a baseline control for diet and sleep and none discussed the possible reversal of withdrawal effect due to pre-experimental fasting. For demographic factors, caffeine may interact with sex and age, and the direction of the effect may depend on the dose, individual tolerance, and metabolism at baseline. Future studies should incorporate these considerations, as well as providing continued evidence on the effect of caffeine in visuospatial, prospective, and implicit memory measures.

Automated summary

Studies have found that caffeine can affect performance in memory tasks, but the evidence is limited, especially in memory performance beyond improved reaction times. Drug factors, experimental factors, and demographic factors may all play a role in modulating the effects of caffeine on memory, with inconsistent findings and potential interactions with various aspects such as dose, source, experimental design, and individual differences.