4.5 Article

Diminished Cold Avoidance Behaviours after Chronic Cold Exposure-Potential Involvement of TRPM8

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Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits

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Summary: TRPM8 is the principal detector of environmental cold in mammalian sensory nerve endings, and it is also expressed in restricted areas of the central nervous system, especially in regions like the hypothalamus and septum. The presence of TRPM8-expressing central neurons in different areas of the brain suggests a potential role in thermal regulation, which has been confirmed by electrophysiological recordings in mouse brain.

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