期刊
NEURON
卷 109, 期 15, 页码 2380-2397出版社
CELL PRESS
DOI: 10.1016/j.neuron.2021.05.017
关键词
-
资金
- CCA-Inserm Bettencourt clinicalscientist fellowship from Fondation Bettencourt Schueller
The translational research on PTSD has seen limited improvements in clinical practice, primarily due to the ill-defined variety of fear conditioning-based models. This article takes a historical and conceptual approach to address these issues and suggests future research directions involving transdisciplinary collaboration.
Translational research on post-traumatic stress disorder (PTSD) has produced limited improvements in clinical practice. Fear conditioning (FC) is one of the dominant animal models of PTSD. In fact, FC is used in many different ways to model PTSD. The variety of FC-based models is ill defined, creating confusion and conceptual vagueness, which in turn impedes translation into the clinic. This article takes a historical and conceptual approach to provide a comprehensive picture of current research and help reorient the research focus. This work historically reviews the variety of models that have emerged from the initial association of PTSD with FC, highlighting conceptual pitfalls that have limited the translation of animal research into clinical advances. We then provide some guidance on how future translational research could benefit from conceptual and technological improvements to translate basic findings in patients. This objective will require transdisciplinary approaches and should involve physicians, engineers, philosophers, and neuroscientists.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据