Targeting Mitochondrial Oxidative Phosphorylation in Glioblastoma Therapy

As a multi-functional cellular organelle, mitochondrial metabolic reprogramming is well recognized as a hallmark of cancer. The center of mitochondrial metabolism is oxidative phosphorylation (OXPHOS), in which cells use enzymes to oxidize nutrients, thereby converting the chemical energy to the biological energy currency ATPs. OXPHOS also creates the mitochondrial membrane potential and serve as the driving force of other mitochondrial metabolic pathways and experiences significant reshape in the different stages of tumor progression. In this minireview, we reviewed the major mitochondrial pathways that are connected to OXPHOS and are affected in cancer cells. In addition, we summarized the function of novel bio-active molecules targeting mitochondrial metabolic processes such as OXPHOS, mitochondrial membrane potential and mitochondrial dynamics. These molecules exhibit intriguing preclinical and clinical results and have been proven to be promising antitumor candidates in recent studies.

Automated summary

Mitochondrial metabolic reprogramming, specifically oxidative phosphorylation (OXPHOS), plays a key role in cancer progression by converting nutrients to ATP and creating mitochondrial membrane potential. This process undergoes significant changes during different stages of tumor progression. Targeting mitochondrial metabolic processes with novel bio-active molecules has shown promising results as potential antitumor candidates in recent studies.