4.7 Article

Reversible Cerebral Vasoconstriction Syndrome Symptoms, Incidence, and Resource Utilization in a Population-Based US Cohort

期刊

NEUROLOGY
卷 97, 期 3, 页码 E248-E253

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000012223

关键词

-

资金

  1. New York State Empire Clinical Research Investigator Program
  2. Leon Levy Foundation in Neuroscience
  3. American Heart Association [18CDA34110419]
  4. NIH [K23NS091395]
  5. Florence Gould Endowment for Discovery in Stroke

向作者/读者索取更多资源

The study estimated the age- and sex-standardized incidence of hospitalization for reversible cerebral vasoconstriction syndrome (RCVS) in US adults to be approximately 3 cases per million per year. Many patients with RCVS had concomitant neurologic diagnoses, including subarachnoid hemorrhage, ischemic stroke, and intracerebral hemorrhage.
Objective To estimate the incidence of hospitalization for reversible cerebral vasoconstriction syndrome (RCVS), we identified RCVS-related hospital admissions across 11 US states in 2016. Methods We tested the validity of ICD-10 code 167.841 in 79 patients with hospital admissions for RCVS or other cerebrovascular diseases at 1 academic and 1 community hospital. After determining that this code had a sensitivity of 100% (95% confidence interval [CI], 82%-100%) and a specificity of 90% (95% CI, 79%-96%), we applied it to administrative data from the Healthcare Cost and Utilization Project on all hospital admissions across 11 states. Age- and sex-standardized RCVS incidence was calculated using census data. Descriptive statistics were used to analyze associated diagnoses. Results Across 5,067,250 hospital admissions in our administrative data, we identified 222 patients with a discharge diagnosis of RCVS in 2016. The estimated annual age- and sex-standardized incidence of RCVS hospitalization was 2.7 (95% CI, 2.4-3.1) cases per million adults. Many patients had concomitant neurologic diagnoses, including subarachnoid hemorrhage (37%), ischemic stroke (16%), and intracerebral hemorrhage (10%). In the 90 days before the index admission, 97 patients had an emergency department (ED) visit and 34 patients a hospital admission, most commonly for neurologic, psychiatric, and pregnancy-related diagnoses. Following discharge from the RCVS hospital admission, 58 patients had an ED visit and 31 had a hospital admission, most commonly for neurologic diagnoses. Conclusions Using population-wide data, we estimated the age- and sex-standardized incidence of hospitalization for RCVS in US adults as approximately 3 per million per year.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据