期刊
NEUROBIOLOGY OF DISEASE
卷 157, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2021.105445
关键词
Exosome; Microvesicle; Ectosome; Extracellular vesicle; Neurological disease
资金
- American Epilepsy Society
- NIH [5T32NS096050-24]
Extracellular vesicles (EVs) are cell-derived membranous particles that contain various molecules and play important roles in intercellular communication. They have shown efficacy in models of neurological disorders by reducing symptoms and providing benefits, making them a promising avenue for future research and clinical applications.
Extracellular vesicles (EVs) are small, cell-derived membranous particles containing various nucleic acids, proteins, and lipids that play essential roles in intercellular communication. Evidence indicating that part of the regenerative benefit from stem cell therapy arises through EVs released from transplanted cells created interest in using EVs for clinical applications. EVs from various cellular sources, including mesenchymal stem cells, neural stem cells, and glia, are efficacious in models of neurological disease. In these models, EVs attenuate reactive gliosis, neuronal death, pro-inflammatory signaling, as well as reduce cognitive, behavioral, and motor deficits. EVs are naturally permeable to the blood-brain barrier and can be modified to contain molecules of interest, thereby also serving as a vehicle to transport therapeutics into the brain. This review summarizes the current state of research using EVs as a treatment in models of neurological disorders and highlights considerations for future research.
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