期刊
NEUROBIOLOGY OF AGING
卷 109, 期 -, 页码 113-124出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2021.09.012
关键词
Working memory; In vitro slice; Electrophysiology; Morphology; Delayed Recognition Span Task
资金
- National Institute on Aging [R01-AG059028, R01-AG043478, R01-AG043640]
A study found that layer 3 pyramidal neurons in the lateral prefrontal cortex of aged rhesus monkeys exhibit increased excitability and reduced spine density, while middle-aged monkeys given curcumin showed better working memory performance and less neuronal excitability.
Layer 3 (L3) pyramidal neurons in aged rhesus monkey lateral prefrontal cortex (LPFC) exhibit significantly elevated excitability in vitro and reduced spine density compared to neurons in young subjects. The time-course of these alterations, and whether they can be ameliorated in middle age by the powerful anti-oxidant curcumin is unknown. We compared the properties of L3 pyramidal neurons from the LPFC of behaviorally characterized rhesus monkeys over the adult lifespan using whole-cell patch clamp recordings and neuronal reconstructions. Working memory (WM) impairment, neuronal hyperexcitability, and spine loss began in middle age. There was no significant relationship between neuronal properties and WM performance. Middle-aged subjects given curcumin exhibited better WM performance and less neuronal excitability compared to control subjects. These findings suggest that the appropriate time frame for intervention for age-related cognitive changes is early middle age, and points to the efficacy of cur cumin in delaying WM decline. Because there was no relationship between excitability and behavior, the effects of curcumin on these measures appear to be independent. (c) 2021 Elsevier Inc. All rights reserved.
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