期刊
NEURO-ONCOLOGY
卷 23, 期 10, 页码 1634-1646出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/noab138
关键词
BRAF; cellular senescence; low-grade glioma; MEK; neurofibromatosis type 1; pediatric brain tumor; pilocytic astrocytoma; tumor microenvironment
资金
- National Institutes of Health [1-R35-NS07211-01]
- Schnuck Markets, Inc.
- Brain Tumor Charity (TBTC, The Everest Centre for Low-Grade Pediatric Brain Tumours) [GN-000382]
- DKTK German Cancer Consortium (Joint Funding Next Gen LOGGIC)
- CDC [75D30119C06056]
- American Brain Tumor Association
- Sontag Foundation
- Novocure
- Musella Foundation
- National Brain Tumor Society
- Pediatric Brain Tumor Foundation
- Uncle Kory Foundation
- Zelda Dorin Tetenbaum Memorial Fund
pLGGs are the most common brain tumor in children, but our understanding of their molecular and cellular pathogenesis remains incomplete. Despite the identification of pathogenic driver mutations, it is now recognized that these mutations may not be sufficient for gliomagenesis and clinical progression.
Pediatric low-grade gliomas (pLGGs) are the most common brain tumor in children and are associated with life-long clinical morbidity. Relative to their high-grade adult counterparts or other malignant childhood brain tumors, there is a paucity of authenticated preclinical models for these pLGGs and an incomplete understanding of their molecular and cellular pathogenesis. While large-scale genomic profiling efforts have identified the majority of pathogenic driver mutations, which converge on the MAPK/ERK signaling pathway, it is now appreciated that these events may not be sufficient by themselves for gliomagenesis and clinical progression. In light of the recent World Health Organization reclassification of pLGGs, and pilocytic astrocytoma (PA), in particular, we review our current understanding of these pediatric brain tumors, provide a conceptual framework for future mechanistic studies, and outline the challenges and pressing needs for the pLGG clinical and research communities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据