期刊
FUNDAMENTAL & CLINICAL PHARMACOLOGY
卷 31, 期 1, 页码 64-74出版社
WILEY
DOI: 10.1111/fcp.12229
关键词
advanced oxidation protein products; apoptosis; endoplasmic reticulum stress; human chondrocyte; mitochondria membrane potential; reactive oxygen species
资金
- National Natural Science Foundation of China [81272042]
Advanced oxidation production products (AOPPs) have been confirmed to accumulate in patients with rheumatoid arthritis (RA). Previous study demonstrated that AOPPs could accelerate cartilage destruction in rabbit arthritis model. However, the effect of AOPP stimulation on apoptosis of human chondrocyte and the underlying mechanisms remains unclear. This study demonstrated that exposure of chondrocyte to AOPPs resulted in cell apoptosis. AOPP stimulation triggered reactive oxygen species (ROS) production, which induced mitochondrial dysfunction and endoplasmic reticulum stress (ER stress) resulted in caspase activation. Furthermore, an antioxidant, N-acetylcysteine, markedly blocked these signals. Our study demonstrated that AOPPs induce apoptosis via ROS-related mitochondria- and ER-dependent signals in human chondrocyte. Targeting AOPP-triggered ROS generation might be as a promising option for patients with RA.
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