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Covid-19 and development of heart failure: mystery and truth

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

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Heart failure and COVID-19

Feras Bader et al.

Summary: Heart failure is a common disease state that may occur in COVID-19 patients, presenting unique challenges that require careful understanding of hemodynamics and diagnostics for appropriate triage and management. Abnormal cardiac biomarkers in COVID-19 are influenced by various mechanisms, including viral entry, direct cardiac injury, increased thrombotic activity, and stress cardiomyopathy. Understanding the interaction between heart failure medications, COVID-19 treatments, and managing patients with advanced therapies is crucial for optimal care.

HEART FAILURE REVIEWS (2021)

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Article Biochemistry & Molecular Biology

In silico identification of widely used and well-tolerated drugs as potential SARS-CoV-2 3C-like protease and viral RNA-dependent RNA polymerase inhibitors for direct use in clinical trials

Seref Gul et al.

Summary: Despite the lack of clinically proven drugs for COVID-19, computationally screening clinically approved drugs has identified potential candidates for antiviral treatment.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Review Biology

The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections

Mohamed Moubarak et al.

Summary: Novel therapies for COVID-19 continue to emerge as the pandemic progresses, with PCR as the standard for initial diagnosis and advances in immunological profiling guiding treatment. Multiple mutations in SARS-Cov-2 have resulted in changes in virulence globally, presenting challenges for disease control. The emergence of more virulent variants impacts the severity of the disease and affects effective control during this pandemic.

LIFE-BASEL (2021)

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Review Virology

The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV

Nima Hemmat et al.

Summary: The number of descriptions of emerging viruses has increased rapidly since the beginning of the 21st century. SARS-CoV-2 may cause inflammation at the onset of COVID-19 through NF-kappa B, cytokine regulation, ERK, and TNF-alpha signaling pathways. Some drugs have been used to alleviate the adverse effects of inflammatory cellular signaling pathways and may be beneficial for developing novel therapeutic modalities against COVID-19.

ARCHIVES OF VIROLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Promising Therapy for Heart Failure in Patients with Severe COVID-19: Calming the Cytokine Storm

Xiang Peng et al.

Summary: The COVID-19 pandemic poses a global threat to health and economy, with accumulating evidence showing damage not only to the lungs but also to the cardiovascular system. Cytokine storm plays a key role in the progression of COVID-19, especially in patients with pre-existing or new onset myocardial damage and heart failure, making it a novel focus for therapies.

CARDIOVASCULAR DRUGS AND THERAPY (2021)

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Review Pharmacology & Pharmacy

SARS-CoV-2-mediated hyperferritinemia and cardiac arrest: preliminary insights

Prakash VasanthiDharmalingam et al.

Summary: SARS-CoV-2, which originated in China, infects humans through the ACE-2 receptor and co-receptors, causing pneumonia and multiple organ failure. Reports suggest that cardiac dysfunction in SARS-CoV-2 patients may result in high death rates, but the underlying cause and mechanisms are still unknown. Some clinical reports propose that hyperferritinemia could be a potential mechanism contributing to cardiac dysfunction in SARS-CoV-2 patients.

DRUG DISCOVERY TODAY (2021)

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Review Cell Biology

Multi-organ damage by covid-19: congestive (cardio-pulmonary) heart failure, and blood-heart barrier leakage

Suresh C. Tyagi et al.

Summary: Covid-19 is caused by a coronavirus known as SARS-CoV-2, and is characterized by fever, respiratory inflammation, and multi-organ failure. Treatment options such as using angiotensinogen blockers and doxycycline may benefit patients. Further research is ongoing to investigate potential interventions to mitigate the multi-organ damage caused by Covid-19.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

From Angiotensin II to Cyclic Peptides and Angiotensin Receptor Blockers (ARBs): Perspectives of ARBs in COVID-19 Therapy

John Matsoukas et al.

Summary: Angiotensin II is a widely studied hormone that has led to the design and synthesis of non-peptide drugs. These drugs have made breakthroughs in the treatment of hypertension and were widely marketed in the 1990s. Recent studies have found that RAS inhibitors can help resist SARS-CoV-2 infection, maintain homeostasis, and vasodilation.

MOLECULES (2021)

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Article Cardiac & Cardiovascular Systems

Clinical Outcomes in Patients With Heart Failure Hospitalized With COVID-19

Ankeet S. Bhatt et al.

Summary: This study found that patients with a history of HF hospitalized with COVID-19 have a higher mortality rate, with nearly one in four patients dying during hospitalization.

JACC-HEART FAILURE (2021)

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Review Chemistry, Medicinal

COVID-19-The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection

Katarzyna Kotfis et al.

Summary: Spironolactone has been shown to have potential benefits in preventing pulmonary fibrosis in COVID-19 infection, and its potassium-sparing diuretic action may also be beneficial in COVID-19 ARDS. As a well-known and widely used medication, spironolactone's pleiotropic effects could offer therapeutic benefits to patients with COVID-19 pneumonia.

PHARMACEUTICALS (2021)

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Review Pharmacology & Pharmacy

PDE4 inhibition as a therapeutic strategy for improvement of pulmonary dysfunctions in Covid-19 and cigarette smoking

Claire Lugnier et al.

Summary: ACE2 serves as the entry point for SARS-CoV-2, with chronic smoking leading to upregulation of bronchial ACE2 and potentially increasing vulnerability to COVID-19 infection in smokers. Smoking-induced dysregulation of RAS may contribute to the pathogenesis of COVID-19 pneumonia, but the main pathway appears to involve AngII/AT1R inducing an inflammatory response in COVID-19, potentially through upregulation of PDE4.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Biochemical Research Methods

Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients

Tasnimul Alam Taz et al.

Summary: This study aimed to identify significant gene expression profiles in human lung epithelial cells caused by SARS-CoV-2 infections, with comparative genomic analysis showing differences between SARS-CoV and SARS-CoV-2. Transcriptomic analysis revealed gene expression similarities between SARS-CoV-2 infection responses and PAH lungs, leading to the identification of potential therapeutic targets for COVID-19, including shared signaling pathways and drug compounds.

BRIEFINGS IN BIOINFORMATICS (2021)

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Letter Cardiac & Cardiovascular Systems

Atrial fibrillation and flutter in patients hospitalized for COVID-19: The challenging role of digoxin

Eftychios Siniorakis et al.

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2021)

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Article Medicine, General & Internal

COVID-19 and Risk of Acute Ischemic Stroke and Acute Lung Injury in Patients With Type II Diabetes Mellitus: The Anti-inflammatory Role of Metformin

Hayder M. Al-kuraishy et al.

Summary: Metformin therapy in type 2 diabetes patients with COVID-19 was associated with a lower risk of acute ischemic stroke (AIS). Metformin-treated patients showed lower levels of ferritin, CRP, LDH, and D-dimer compared to non-metformin treated patients, as well as lower lung CT scan scores. Further studies are needed to explore the relationship between AIS in COVID-19 diabetic patients and metformin therapy.

FRONTIERS IN MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Case Report: Hyperbilirubinemia in Gilbert Syndrome Attenuates Covid-19-Induced Metabolic Disturbances

Hayder M. Al-kuraishy et al.

Summary: This study described a case of a 47-year-old man with Gilbert syndrome (GS) who was diagnosed with Covid-19 pneumonia. The patient with GS showed a rapid clinical recovery and shorter hospital stay compared to other Covid-19 patients, suggesting that hyperbilirubinemia may have a protective effect. The data suggests that the higher resistance against Covid-19 observed in the GS patient may be due to the antioxidant, anti-inflammatory, and antiviral effects of unconjugated bilirubin.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Review Pharmacology & Pharmacy

Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: The enigmatic entity

Hayder M. Al-kuraishy et al.

Summary: SARS-CoV-2 virus enters the body through interaction with ACE2 receptors, leading to various clinical manifestations. Leukotriene inhibitors may play an important role in Covid-19 management by blocking CysLTRs or the NF-kappa B signaling pathway to alleviate symptoms.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Computational Identification of Potential Anti-Inflammatory Natural Compounds Targeting the p38 Mitogen-Activated Protein Kinase (MAPK): Implications for COVID-19-Induced Cytokine Storm

Seth O. Asiedu et al.

Summary: This study identified potential natural product-derived inhibitors against the p38 alpha MAPK receptor to reduce pro-inflammatory cytokine production in severely ill COVID-19 patients. The molecules showed strong bonds with critical residues and low binding energies, suggesting they could be promising therapeutic candidates against the cytokine storm.

BIOMOLECULES (2021)

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Review Nutrition & Dietetics

The Looming Effects of Estrogen in Covid-19: A Rocky Rollout

Hayder M. Al-kuraishy et al.

Summary: Studies have shown that women have a powerful immunomodulating effect against Covid-19 through the effect of estrogen. Estrogens have significant anti-inflammatory and immuno-modulatory effects in Covid-19, reducing SARS-CoV-2 infectivity. Future clinical trials and prospective studies will help elucidate and confirm the protective effect of estrogen against Covid-19.

FRONTIERS IN NUTRITION (2021)

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Meeting Abstract Cardiac & Cardiovascular Systems

Clinical characteristics and outcomes of patients with heart failure admitted to the intensive care unit with coronavirus disease 2019 (COVID19): a multicenter cohort study

H. Badreldin et al.

EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING (2021)

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Article Cell Biology

The potential role of neopterin in Covid-19: a new perspective

Hayder M. Al-kuraishy et al.

Summary: NPT is a member of pteridines group synthesized by macrophages, which is regarded as a macrophage stimulation indicator and immune response marker, with potential independent prognostic significance in Covid-19. Early elevation of NPT levels may indicate the activation status of inflammatory cells.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

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Article Cardiac & Cardiovascular Systems

Cardiovascular comorbidities as predictors for severe COVID-19 infection or death

Matthew Phelps et al.

Summary: The study in Denmark found that pre-existing cardiovascular diseases may predict the 30-day risk of severe COVID-19 and all-cause mortality, but the effects are not very significant. This suggests that more tailored guidance can be provided to cardiovascular patients in managing their risk of poor COVID-19 outcomes.

EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES (2021)

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Letter Cardiac & Cardiovascular Systems

SARS-CoV-2: a potential novel etiology of fulminant myocarditis

Chen Chen et al.

HERZ (2020)

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Article Medicine, General & Internal

Carvedilol and COVID-19: A Potential Role in Reducing Infectivity and Infection Severity

Charbel Skayem et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2020)

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Article Cardiac & Cardiovascular Systems

Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic

Zahra Belhadjer et al.

CIRCULATION (2020)

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Editorial Material Medicine, General & Internal

COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers What Is the Evidence?

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Joint HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19

Biykem Bozkurt et al.

JOURNAL OF CARDIAC FAILURE (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Review Cardiac & Cardiovascular Systems

COVID-19 pandemic and troponin: indirect myocardial injury, myocardial inflammation or myocarditis?

Massimo Imazio et al.

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Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 201p

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Review Biochemistry & Molecular Biology

Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions

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Article Peripheral Vascular Disease

Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

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SCIENTIFIC REPORTS (2020)

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Classical Drug Digitoxin Inhibits Influenza Cytokine Storm, With Implications for Covid-19 Therapy

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Is ivermectin-Azithromycin combination the next step for COVID-19?

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The clinical significance of interleukin-6 in heart failure: results from the BIOSTAT-CHF study

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The Unraveled Link Between Antiviral Therapy and Heart Failure Hospitalization in Chronic Hepatitis C Virus Infection - A Nationwide Cohort Study -

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