Is it a wrap? Nucleosome interactions of the BRCA1-binding partner, BARD1, steal the scene

Emerging findings provide compelling evidence that the BRCA1-binding partner BARD1 contributes yet further to BRCA1 function. BARD1 is crucial for positioning the E2 ubiquitin-conjugating enzyme that confers specificity of its ligase to residues on histone H2A, and BARD1 also promotes DNA damage-induced chromatin recruitment through an interaction with ubiquitin-conjugated Lys13 or Lys15 of H2A on the nucleosome core particle.

Automated summary

New findings show that BARD1, a partner of BRCA1, plays a crucial role in positioning the E2 ubiquitin-conjugating enzyme and promoting DNA damage-induced chromatin recruitment, enhancing the function of BRCA1.