4.7 Review

The mechanisms of integral membrane protein biogenesis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Cryo-EM structures of the endoplasmic reticulum membrane complex

Lin Bai et al.

Summary: Membrane proteins' transmembrane alpha-helices come in highly hydrophobic and less hydrophobic forms, with insertion into the membrane requiring different insertase enzymes. Recent cryo-electron microscopy studies have shown structural conservation of the endoplasmic reticulum membrane complex (EMC) from yeast to humans, a common substrate-binding pocket, and evolutionary similarities to prokaryotic insertases. These findings offer a foundation for future mechanistic research.

FEBS JOURNAL (2022)

Review Cell Biology

Protein Sorting within Chloroplasts

Xiumei Xu et al.

Summary: Chloroplasts have multiple suborganellar membranes, and the correct and efficient translocation of chloroplast proteins is fundamental. Recent studies have explored new components and regulatory mechanisms involved in chloroplast protein import and sorting, including the novel mechanism of liquid-liquid phase transition (LLPT) for regulating chloroplast protein sorting. Overall, LLPT may be a universal and conserved mechanism for organelle protein trafficking and biogenesis.

TRENDS IN CELL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Mechanisms and pathways of mitochondrial outer membrane protein biogenesis

Arushi Gupta et al.

Summary: Outer membrane proteins play crucial roles in integrating mitochondria into the cellular environment, facilitating exchange of metabolites and ions, forming signaling platforms for apoptosis and inflammation, and mediating organelle fusion and fission. These proteins, produced by cytosolic ribosomes, are imported into the target organelle via distinct import routes.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2021)

Article Biochemistry & Molecular Biology

Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks

William M. Schneider et al.

Summary: The study revealed the host factors and pathways involved in SARS-CoV-2 and seasonal coronavirus infections, providing a rich resource for developing therapeutic strategies for future coronavirus pandemics.
Article Biochemistry & Molecular Biology

Ring assembly of c subunits of F0F1-ATP synthase in Propionigenium modestum requires YidC and UncI following MPIase-dependent membrane insertion

Hanako Nishikawa et al.

Summary: The membrane insertion and subsequent ring assembly of Pm-F(0)c depend on MPIase, YidC, and Pm-UncI, with successful reconstitution observed in liposomes containing E. coli phospholipids.

FEBS LETTERS (2021)

Article Biochemistry & Molecular Biology

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62

Samuel Itskanov et al.

Summary: The cryo-EM structures of fungal Sec61-Sec62-Sec63 complexes reveal the hierarchical activation of the Sec61 channel by Sec62 and Sec63, facilitating post-translational protein translocation into the endoplasmic reticulum.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Molecular basis of tail-anchored integral membrane protein recognition by the cochaperone Sgt2

Ku-Feng Lin et al.

Summary: Sgt2 and SGTA serve as entry points for the GET pathway, interacting with TA IMPs to facilitate their insertion into the correct membrane. The flexible and conserved C-terminal domain of Sgt2 is sufficient for client binding, forming a helical hand with a hydrophobic groove for higher affinity interaction with client TMDs. These findings highlight structural similarities between Sgt2 and other TPR-containing cochaperone proteins, such as Sti1.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily

Melanie A. McDowell et al.

Summary: Recent studies on eukaryotic membrane protein insertases of the Oxa1 superfamily have shown a conserved protein module and common mechanistic principles for inserting a diverse set of substrates into membranes. Members of the Oxa1 superfamily carry out membrane protein insertion in bacteria, the eukaryotic endoplasmic reticulum (ER), and endosymbiotic organelles, with similarities in structure and function to their bacterial counterpart YidC.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Article Multidisciplinary Sciences

Mechanism of membrane-tethered mitochondrial protein synthesis

Yuzuru Itoh et al.

Summary: The study reveals the mechanism of interaction between human mitoribosomes and the insertase OXA1L, elucidating how membrane delivery is achieved during protein synthesis.

SCIENCE (2021)

Article Biochemistry & Molecular Biology

WNK1 is an assembly factor for the human ER membrane protein complex

Tino Pleiner et al.

Summary: The assembly of nascent proteins into multi-subunit complexes is regulated by WNK1, which stabilizes EMC2 and promotes assembly of EMC, playing a key role in cellular homeostasis. Depletion of WNK1 destabilizes both EMC and its membrane protein clients.

MOLECULAR CELL (2021)

Review Biochemistry & Molecular Biology

Detecting and Rescuing Stalled Ribosomes

Matthew C. J. Yip et al.

Summary: This article discusses the advancements in our mechanistic understanding of detecting and rescuing stalled ribosomal complexes in eukaryotes, including selectively detecting rare aberrant translational complexes, processing heterogeneous components, eliminating problematic RNA and nascent proteins through quality control pathways, and ensuring nascent proteome integrity through fail-safe mechanisms.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Review Cell Biology

Translocation of Proteins through a Distorted Lipid Bilayer

Xudong Wu et al.

Summary: The membranes surrounding cells or organelles act as barriers for proteins and molecules, but certain proteins can cross through different translocation systems. Recent studies show that in some cases, an aqueous pore is not necessary for protein translocation to occur.

TRENDS IN CELL BIOLOGY (2021)

Article Multidisciplinary Sciences

Pervasive functional translation of noncanonical human open reading frames

Jin Chen et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Structural basis for membrane insertion by the human ER membrane protein complex

Tino Pleiner et al.

SCIENCE (2020)

Review Biochemistry & Molecular Biology

Cytosolic Events in the Biogenesis of Mitochondrial Proteins

Yury S. Bykov et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

Article Cell Biology

Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex

Alison J. Inglis et al.

CELL REPORTS (2020)

Article Biochemistry & Molecular Biology

Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

Dale Tranter et al.

ACS CHEMICAL BIOLOGY (2020)

Article Multidisciplinary Sciences

Structure of the ER membrane complex, a transmembrane-domain insertase

Lin Bai et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

C-terminal tail length guides insertion and assembly of membrane proteins

Sha Sun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex

Melanie A. McDowell et al.

MOLECULAR CELL (2020)

Article Multidisciplinary Sciences

An intramembrane chaperone complex facilitates membrane protein biogenesis

Patrick J. Chitwood et al.

NATURE (2020)

Article Biology

An ER translocon for multi-pass membrane protein biogenesis

Philip T. McGilvray et al.

Review Cell Biology

Ribosome-associated quality control of membrane proteins at the endoplasmic reticulum

Ben P. Phillips et al.

JOURNAL OF CELL SCIENCE (2020)

Article Multidisciplinary Sciences

The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase

Michael J. McKenna et al.

SCIENCE (2020)

Article Biotechnology & Applied Microbiology

SignalP 5.0 improves signal peptide predictions using deep neural networks

Jose Juan Almagro Armenteros et al.

NATURE BIOTECHNOLOGY (2019)

Review Plant Sciences

Biogenesis of chloroplast outer envelope membrane proteins

Jonghak Kim et al.

PLANT CELL REPORTS (2019)

Review Cell Biology

The Role of EMC during Membrane Protein Biogensis

Patrick J. Chitwood et al.

TRENDS IN CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Insertion and folding pathways of single membrane proteins guided by translocases and insertases

Tetiana Serdiuk et al.

SCIENCE ADVANCES (2019)

Article Chemistry, Multidisciplinary

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Guanghui Zong et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Cell Biology

Mechanisms and functions of ribosome-associated protein quality control

Claudio A. P. Joazeiro

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Cell Biology

Versatility of Preprotein Transfer from the Cytosol to Mitochondria

Thomas Becker et al.

TRENDS IN CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC

Martin Gamerdinger et al.

MOLECULAR CELL (2019)

Review Biochemistry & Molecular Biology

The Ways of Tails: the GET Pathway and more

Nica Borgese et al.

PROTEIN JOURNAL (2019)

Article Biochemistry & Molecular Biology

The molecular mechanism of cotranslational membrane protein recognition and targeting by SecA

Shuai Wang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Guiding tail-anchored membrane proteins to the endoplasmic reticulum in a chaperone cascade

Shu-ou Shan

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Msp1 Clears Mistargeted Proteins by Facilitating Their Transfer from Mitochondria to the ER

Shunsuke Matsumoto et al.

MOLECULAR CELL (2019)

Article Biochemistry & Molecular Biology

New Insights into Amino-Terminal Translocation as Revealed by the Use of YidC and Sec Depletion Strains

Sri Karthika Shanmugam et al.

JOURNAL OF MOLECULAR BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation

Dara E. Leto et al.

MOLECULAR CELL (2019)

Article Multidisciplinary Sciences

The ER membrane protein complex is a transmembrane domain insertase

Alina Guna et al.

SCIENCE (2018)

Review Biochemistry & Molecular Biology

Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control

Alina Guna et al.

CURRENT BIOLOGY (2018)

Review Cell Biology

Mechanistic insights into ER-associated protein degradation

Xudong Wu et al.

CURRENT OPINION IN CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Substrate relay in an Hsp70-cochaperone cascade safeguards tail-anchored membrane protein targeting

Hyunju Cho et al.

EMBO JOURNAL (2018)

Article Biochemistry & Molecular Biology

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins

Sandra Stefanovic-Barrett et al.

EMBO REPORTS (2018)

Article Biochemistry & Molecular Biology

SRP, FtsY, DnaK and YidC Are Required for the Biogenesis of the E. coli Tail-Anchored Membrane Proteins DjIC and Flk

Markus Peschke et al.

JOURNAL OF MOLECULAR BIOLOGY (2018)

Article Multidisciplinary Sciences

Structure of a prehandover mammalian ribosomal SRP.SRP receptor targeting complex

Kan Kobayashi et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Defining the physiological role of SRP in protein-targeting efficiency and specificity

Elizabeth A. Costa et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

The interaction network of the YidC insertase with the SecYEG translocon, SRP and the SRP receptor FtsY

Narcis-Adrian Petriman et al.

SCIENTIFIC REPORTS (2018)

Review Biochemistry & Molecular Biology

Quality Control of Orphaned Proteins

Szymon Juszkiewicz et al.

MOLECULAR CELL (2018)

Review Cell Biology

Regulation of proteasome assembly and activity in health and disease

Adrien Rousseau et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

Patrick J. Chitwood et al.

Article Microbiology

SecA Cotranslationally Interacts with Nascent Substrate Proteins In Vivo

Damon Huber et al.

JOURNAL OF BACTERIOLOGY (2017)

Article Biochemistry & Molecular Biology

hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells

Sarah Hassdenteufel et al.

FEBS LETTERS (2017)

Article Cell Biology

SecA mediates cotranslational targeting and translocation of an inner membrane protein

Shuai Wang et al.

JOURNAL OF CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins

Matthew L. Wohlever et al.

MOLECULAR CELL (2017)

Review Microbiology

The β-barrel assembly machinery in motion

Nicholas Noinaj et al.

NATURE REVIEWS MICROBIOLOGY (2017)

Article Multidisciplinary Sciences

Mechanistic basis for a molecular triage reaction

Sichen Shao et al.

SCIENCE (2017)

Article Cell Biology

Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer

Benjamin E. Zalisko et al.

CELL REPORTS (2017)

Article Multidisciplinary Sciences

Structure of the Sec61 channel opened by a signal sequence

Rebecca M. Voorhees et al.

SCIENCE (2016)

Article Biochemistry & Molecular Biology

Targeting and insertion of peroxisomal membrane proteins: ER trafficking versus direct delivery to peroxisomes

Peter U. Mayerhofer

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Article Biochemistry & Molecular Biology

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

Erik McShane et al.

Article Biochemistry & Molecular Biology

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation

Eisuke Itakura et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Cotranslational signal-independent SRP preloading during membrane targeting

Justin W. Chartron et al.

NATURE (2016)

Article Multidisciplinary Sciences

Global profiling of SRP interaction with nascent polypeptides

Daniela Schibich et al.

NATURE (2016)

Article Multidisciplinary Sciences

Crystal structure of a substrate-engaged SecY protein-translocation channel

Long Li et al.

NATURE (2016)

Article Multidisciplinary Sciences

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

Caleb D. Marceau et al.

NATURE (2016)

Review Biochemistry & Molecular Biology

Ribosome-associated protein quality control

Onn Brandman et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Review Biochemistry & Molecular Biology

The GroEL-GroES Chaperonin Machine: A Nano-Cage for Protein Folding

Manajit Hayer-Hartl et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Review Biochemistry & Molecular Biology

Ribosome-associated protein quality control

Onn Brandman et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Multidisciplinary Sciences

A central cavity within the holo-translocon suggests a mechanism for membrane protein insertion

Mathieu Botte et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo

Jhon Rivera-Monroy et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum

Martin Gamerdinger et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Structure of the Get3 targeting factor in complex with its membrane protein cargo

Agnieszka Mateja et al.

SCIENCE (2015)

Article Biochemistry & Molecular Biology

A YidC-like Protein in the Archaeal Plasma Membrane

Marta T. Borowska et al.

STRUCTURE (2015)

Article Multidisciplinary Sciences

Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain

Jee-Young Mock et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Biophysics

Fidelity of Cotranslational Protein Targeting by the Signal Recognition Particle

Xin Zhang et al.

ANNUAL REVIEW OF BIOPHYSICS, VOL 43 (2014)

Review Biochemistry & Molecular Biology

SecA-mediated targeting and translocation of secretory proteins

Katerina E. Chatzi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

Review Biochemistry & Molecular Biology

Small membrane proteins - elucidating the function of the needle in the haystack

Grant Kemp et al.

BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

Rebecca M. Voorhees et al.

Article Biochemistry & Molecular Biology

Cytosolic Quality Control of Mislocalized Proteins Requires RNF126 Recruitment to Bag6

Monica C. Rodrigo-Brenni et al.

MOLECULAR CELL (2014)

Article Multidisciplinary Sciences

Structural basis of Sec-independent membrane protein insertion by YidC

Kaoru Kumazaki et al.

NATURE (2014)

Review Biochemistry & Molecular Biology

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

John C. Christianson et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4

Harry B. Gristick et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins

Voytek Okreglak et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway

Michael E. Rome et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase

Kaoru Kumazaki et al.

SCIENTIFIC REPORTS (2014)

Article Biochemistry & Molecular Biology

Post-translational membrane insertion of an endogenous YidC substrate

Philip J. Robinson et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Review Biochemistry & Molecular Biology

Co-translational targeting and translocation of proteins to the endoplasmic reticulum

Yvonne Nyathi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Biochemistry & Molecular Biology

YidC Occupies the Lateral Gate of the SecYEG Translocon and Is Sequentially Displaced by a Nascent Membrane Protein

Ilie Sachelaru et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

YidC Protein, a Molecular Chaperone for LacY Protein Folding via the SecYEG Protein Machinery

Lu Zhu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Elucidating the Native Architecture of the YidC: Ribosome Complex

Alexej Kedrov et al.

JOURNAL OF MOLECULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Quality Control of Integral Membrane Proteins by Assembly-Dependent Membrane Integration

Matthias J. Feigel et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex

Magali Richard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae

Mohan Babu et al.

NATURE (2012)

Review Cell Biology

Membrane Protein Insertion at the Endoplasmic Reticulum

Sichen Shao et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

Article Biochemistry & Molecular Biology

M13 Procoat Protein Insertion into YidC and SecYEG Proteoliposomes and Liposomes

Natalie Stiegler et al.

JOURNAL OF MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

YidC-Driven Membrane Insertion of Single Fluorescent Pf3 Coat Proteins

Stefan Ernst et al.

JOURNAL OF MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

The Mechanism of Tail-Anchored Protein Insertion into the ER Membrane

Fei Wang et al.

MOLECULAR CELL (2011)

Article Multidisciplinary Sciences

The mechanism of membrane-associated steps in tail-anchored protein insertion

Malaiyalam Mariappan et al.

NATURE (2011)

Review Multidisciplinary Sciences

Molecular chaperones in protein folding and proteostasis

F. Ulrich Hartl et al.

NATURE (2011)

Review Cell Biology

Tail-anchored membrane protein insertion into the endoplasmic reticulum

Ramanujan S. Hegde et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Structural basis of signal-sequence recognition by the signal recognition particle

Tobias Hainzl et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Multidisciplinary Sciences

Recognition of a signal peptide by the signal recognition particle

Claudia Y. Janda et al.

NATURE (2010)

Article Multidisciplinary Sciences

A ribosome-associating factor chaperones tail-anchored membrane proteins

Malaiyalam Mariappan et al.

NATURE (2010)

Review Biochemistry & Molecular Biology

Biogenesis of beta-barrel membrane proteins in bacteria and eukaryotes: evolutionary conservation and divergence

Dirk M. Walther et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Article Biochemistry & Molecular Biology

YidC is required for the assembly of the MscL homopentameric pore

Ovidiu I. Pop et al.

FEBS JOURNAL (2009)

Article Multidisciplinary Sciences

The structural basis of tail-anchored membrane protein recognition by Get3

Agnieszka Mateja et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Specific transmembrane segments are selectively delayed at the ER translocon during opsin biogenesis

Nurzian Ismail et al.

BIOCHEMICAL JOURNAL (2008)

Article Biochemistry & Molecular Biology

The GET complex mediates insertion of tail-anchored proteins into the ER membrane

Maya Schuldiner et al.

Article Biochemistry & Molecular Biology

Biogenesis of MalF and the MalFGK2 maltose transport complex in Escherichia coli requires YidC

Samuel Wagner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum

Catherine Rabu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Molecular code for transmembrane-helix recognition by the Sec61 translocon

Tara Hessa et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50

Stefan Eimer et al.

EMBO JOURNAL (2007)

Article Biochemistry & Molecular Biology

Identification of a targeting factor for posttranslational membrane protein insertion into the ER

Sandra Stefanovic et al.

Article Biochemistry & Molecular Biology

The mechanosensitive channel protein MscL is targeted by the SRP to the novel YidC membrane insertion pathway of Escherichia coli

Sandra J. Facey et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Review Medicine, General & Internal

The membrane protein universe: what's out there and why bother?

G. von Heijne

JOURNAL OF INTERNAL MEDICINE (2007)

Article Multidisciplinary Sciences

Structure of the E-coli signal recognition particle bound to a translating ribosome

Christiane Schaffitzel et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

Subunit a of cytochrome o oxidase requires both YidC and SecYEG for membrane insertion

DJF du Plessis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA

E van Bloois et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Proteome survey reveals modularity of the yeast cell machinery

AC Gavin et al.

NATURE (2006)

Article Multidisciplinary Sciences

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

NJ Krogan et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

Sequential triage of transmembrane segments by Sec61α during biogenesis of a native multispanning membrane protein

H Sadlish et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)

Review Biochemistry & Molecular Biology

Transmembrane helices before, during, and after insertion

SH White et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2005)

Article Multidisciplinary Sciences

Membrane insertion of a potassium-channel voltage sensor

T Hessa et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

A critical step in the folding of influenza virus HA determined with a novel folding assay

MC Maggioni et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)

Article Cell Biology

Role of YidC in folding of polytopic membrane proteins

S Nagamori et al.

JOURNAL OF CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Escherichia coli YidC is a membrane insertase for Sec-independent proteins

J Serek et al.

EMBO JOURNAL (2004)

Article Biochemistry & Molecular Biology

Molecular mechanism of AHSP-mediated stabilization of α-hemoglobin

L Feng et al.

Article Multidisciplinary Sciences

X-ray structure of a protein-conducting channel

B van den Berg et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

F1F0 ATP synthase subunit c is targeted by the SRP to YidC in the E. coli inner membrane

E van Bloois et al.

FEBS LETTERS (2004)

Article Biochemistry & Molecular Biology

N-linked glycans direct the cotranslational folding pathway of influenza hemagglutinin

R Daniels et al.

MOLECULAR CELL (2003)

Article Multidisciplinary Sciences

An abundant erythroid protein that stabilizes free α-haemoglobin

AJ Kihm et al.

NATURE (2002)

Article Biochemistry & Molecular Biology

The C-elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors

S Halevi et al.

EMBO JOURNAL (2002)

Article Biochemistry & Molecular Biology

Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA

K Hell et al.

EMBO JOURNAL (2001)

Article Multidisciplinary Sciences

The targeting pathway of Escherichia coli presecretory and integral membrane proteins is specified by the hydrophobicity of the targeting signal

HC Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes

A Krogh et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

The α and β subunit of the nascent polypeptide-associated complex have distinct functions

B Beatrix et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Multidisciplinary Sciences

YidC mediates membrane protein insertion in bacteria

JC Samuelson et al.

NATURE (2000)