期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 22, 期 10, 页码 645-646出版社
NATURE PORTFOLIO
DOI: 10.1038/s41580-021-00401-6
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资金
- Deutsche Forschungsgemeinschaft (DFG) in Priority Program 2191 'Molecular Mechanisms of Functional Phase Separation' [RI1283/16-1]
- DFG via the Priority Program 2202 'Spatial Genome Architecture in Development and Disease' [422389065]
- TRR81 Collaborative Research Center [109546710]
Recent studies suggest that phase separation contributes to the formation of 'transcriptional condensates', but the role of intrinsically disordered regions in transcription-relevant factors is crucial in both 'transcriptional condensates' and 'transcription factories'.
Recent studies invoke phase separation as a mechanism underlying the formation of 'transcriptional condensates'. However, similarities between transcriptional condensates and the previously introduced 'transcription factories' model raise the question of what distinguishes the two models. One crucial aspect to consider is the contribution of intrinsically disordered regions in transcription-relevant factors. Rippe and Papantonis suggest that intrinsically disordered regions in transcription-relevant factors underlie the formation of both 'transcriptional condensates' and 'transcription factories'.
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