期刊
NATURE REVIEWS GENETICS
卷 23, 期 1, 页码 5-22出版社
NATURE PORTFOLIO
DOI: 10.1038/s41576-021-00386-0
关键词
-
资金
- NIH [R01 GM117321]
- Paul G. Allen Frontiers Group Distinguished Investigator Award
- Bill and Melinda Gates Foundation
This Review discusses the impact of CRISPR-based gene-drive systems on controlling populations such as insect vectors of disease. It summarizes progress in designing full-drive elements, updating genetic elements, and mitigating strategies, while emphasizing the importance of ethical and social considerations in advancing these technologies towards field implementation.
In this Review, Ethan Bier discusses how several impactful technical advancements, particularly involving CRISPR-based methods, are providing a diverse toolkit of gene-drive systems for the control of populations such as insect vectors of disease. Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian (>50%) frequencies. Recently developed CRISPR-Cas9-based gene-drive systems are highly efficient in laboratory settings, offering the potential to reduce the prevalence of vector-borne diseases, crop pests and non-native invasive species. However, concerns have been raised regarding the potential unintended impacts of gene-drive systems. This Review summarizes the phenomenal progress in this field, focusing on optimal design features for full-drive elements (drives with linked Cas9 and guide RNA components) that either suppress target mosquito populations or modify them to prevent pathogen transmission, allelic drives for updating genetic elements, mitigating strategies including trans-complementing split-drives and genetic neutralizing elements, and the adaptation of drive technology to other organisms. These scientific advances, combined with ethical and social considerations, will facilitate the transparent and responsible advancement of these technologies towards field implementation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据