期刊
NATURE NEUROSCIENCE
卷 24, 期 10, 页码 1392-1401出版社
NATURE PORTFOLIO
DOI: 10.1038/s41593-021-00896-4
关键词
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资金
- National Institutes of Health [R01HD092593, 3R01HD092593-S1, R37NS109478, F31HD098886, NICHD U54HD090257]
- Simons Foundation [572832]
- Children's National Board of Visitors
- Research Foundation of Cerebral Palsy Alliance [3720]
This study reveals that placental ALLO insufficiency alters neurodevelopment in a sex-linked manner, leading to cerebellar white matter abnormalities and autistic-like behavior in male offspring. Gender plays an important role in brain development.
Compromised placental function or premature loss has been linked to diverse neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a progesterone-derived GABA-A receptor (GABA(A)R) modulator, reduction alters neurodevelopment in a sex-linked manner. A new conditional mouse model, in which the gene encoding ALLO's synthetic enzyme (akr1c14) is specifically deleted in trophoblasts, directly demonstrated that placental ALLO insufficiency led to cerebellar white matter abnormalities that correlated with autistic-like behavior only in male offspring. A single injection of ALLO or muscimol, a GABA(A)R agonist, during late gestation abolished these alterations. Comparison of male and female human preterm infant cerebellum also showed sex-linked myelination marker alteration, suggesting similarities between mouse placental ALLO insufficiency and human preterm brain development. This study reveals a new role for a placental hormone in shaping brain regions and behaviors in a sex-linked manner. Placental hormone replacement might offer novel therapeutic opportunities to prevent later neurobehavioral disorders. Placental dysfunction has been implicated in abnormal neurodevelopment. Vacher et al. found that loss of a neuroactive hormone from the placenta alters brain development in a regional and sex-linked manner, resulting in autism-like behaviors in male offspring.
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